Inhibition of the transcription factor C/EBPβ causes both both tumor cell death and macrophage repolarization, a unique combination of cytotoxic and immune-activating functions.

C/EBPβ – a Development Stage Transcription Factor that Drives the Expression of:

  • Survivin (BIRC5), cIAP2 (BIRC3), Bcl family proteins: survival
  • Cyclins: proliferation
  • ID proteins: tumorigenesis
  • CD206, CD209: M2 macrophage polarization
  • IL-6: immune suppression

ST101 MOA

ST101 MOA

Tumor

Sapience Tumor GIF

Tumor Microenvironment

Tumor Microenvironment

Ongoing ST101 Phase 1/2 Clinical Trial

ST101 is currently in the Phase 2 portion of an ongoing Phase 1/2 monotherapy study in patients with recurrent GBM, metastatic cutaneous melanoma, locally advanced or metastatic hormone-receptor positive breast cancer and castration-resistant prostate cancer.

ST101 Clinical Trial