Inhibition of the transcription factor C/EBPβ causes both both tumor cell death and macrophage repolarization, a unique combination of cytotoxic and immune-activating functions.
C/EBPβ – a Development Stage Transcription Factor that Drives the Expression of:
- Survivin (BIRC5), cIAP2 (BIRC3), Bcl family proteins: survival
- Cyclins: proliferation
- ID proteins: tumorigenesis
- CD206, CD209: M2 macrophage polarization
- IL-6: immune suppression
Ongoing ST101 Phase 1/2 Clinical Trial
ST101 is currently in the Phase 2 portion of an ongoing Phase 1/2 monotherapy study in patients with recurrent GBM, metastatic cutaneous melanoma, locally advanced or metastatic hormone-receptor positive breast cancer and castration-resistant prostate cancer.