Preventing β-catenin translocation to the nucleus through disruption of the interaction between BCL9 and β-catenin allows for disruption of oncogenic WNT-signaling, resulting in tumor cell death and a pro-inflammatory tumor microenvironment – without disruption of homeostatic WNT-function.
ST316 suppresses transcription of Wnt target genes regulating proliferation, migration, invasion and the metastatic potential of tumor cells, as well as genes regulating the immunosuppression of the tumor microenvironment.
PHASE 1 ENROLLMENT COMPLETE
As of July 2024, the Phase 1 portion of the ST316 Phase 1-2 study is fully enrolled. Recruitment of the Phase 2 expansion portion will begin in the coming weeks.