Our pipeline of SPEARs™ target transcription factors and regulatory pathways of disease that make cells cancerous or dampen the immune system against tumors

Program/TargetIndication(s)/SettingsDiscoveryIND-EnablingPhase 1Phase 2Phase 3
ST101 C/EBPβ ST101-101 Phase 1/2 Study 
ST101 C/EBPβ Phase 1: Dose Escalation

 
ST101 C/EBPβ All-Comers/Solid

Complete

 
ST101 C/EBPβ Phase 2: Dose Expansion

 
ST101 C/EBPβ Recurrent GBM †*

 
ST101 C/EBPβ Metastatic Cutaneous Melanoma †*

 
ST101 C/EBPβ Castration-Resistant Prostate

 
ST101 C/EBPβ HR+ Breast

 
ST101 C/EBPβ Neo-adjuvant Recurrent GBM †*

 
ST101 C/EBPβ Neo-adjuvant Primary GBM*
(ComboTx)

 
ST316 β-catenin
(Wnt pathway)
Solid 
JunAP cJun (AP1 complex) Solid and heme

 
FoxAP FOXP3 Solid and heme
(ComboTx)

 
ST101 C/EBPβ
ST101-101 Phase 1/2 Study

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

 
ST101 C/EBPβ
Phase 1: Dose Escalation

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

 
ST101 C/EBPβ
All-Comers/Solid

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

Complete

 
ST101 C/EBPβ
Phase 2: Dose Expansion

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

 
ST101 C/EBPβ
Recurrent GBM †*

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

 
ST101 C/EBPβ
Metastatic Cutaneous Melanoma †*

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

 
ST101 C/EBPβ
Castration-Resistant Prostate

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

 
ST101 C/EBPβ
HR+ Breast

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

 
ST101 C/EBPβ
Neo-adjuvant Recurrent GBM †*

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

 
ST101 C/EBPβ
Neo-adjuvant Primary GBM*
(ComboTx)

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

 
ST316 β-catenin
(Wnt pathway)
Solid

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

 
JunAP cJun (AP1 complex)
Solid and heme

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

 
FoxAP FOXP3
Solid and heme
(ComboTx)

Discovery

IND-Enabling

Phase 1

Phase 2

Phase 3

 

†FDA Fast Track Designantion *FDA Orphan Drug Designation