FoxP3 targeted SPEARs generate enhanced anti-tumor immune responses by disrupting FoxP3 homodimers and inhibiting transcription of genes required for Treg development and function.

Forkhead box p3 (FoxP3) is a protein involved in regulation of immune system responses. FoxP3 functions as a master regulator for the development and function of regulatory T cells (Tregs), a subpopulation of T cells that modulate immune responses by suppressing induction and proliferation of effector T cells.

FoxP3 Program Is Currently In Lead Selection

Our FoxP3 SPEAR candidates target the interaction of FoxP3 homodimers and have demonstrated potent inhibition of FoxP3 gene transcription by reporter assay.