Jim Rotolo, Ph.D.

Jim Rotolo is the Senior Vice President of Translational Medicine and Head of Research at Sapience Therapeutics, where he leads the Company’s discovery and pre-clinical development efforts. Prior to Sapience, Dr. Rotolo was Director of Pharmacology at ContraFect Corporation with roles in R&D, non-clinical development and clinical operations. He was responsible for directing in vivo studies supporting the progression of the company’s lead candidate from proof of concept into Phase 2 of clinical development, including PK/PD assessments to inform dose selection for Phase 1 and 2 studies. In addition, Dr. Rotolo designed and directed toxicology, immunogenicity and efficacy experiments to evaluate discovery-phase molecules and in-licensed candidates. Prior to ContraFect, Dr. Rotolo’s research at Memorial Sloan-Kettering Cancer Center culminated in the invention of an engineered antibody-fragment-based therapeutic for medical radiation countermeasures and autoimmune indications. This antibody has been licensed for commercial development and is supported by the NIH Radiation Nuclear Countermeasures Program.

Dr. Rotolo holds a B.S. in Chemistry from Emory University, an M.S. in Pharmacology and Toxicology from Long Island University, and a Ph.D. in Pharmacology and Immunology from the Weill Cornell Graduate School of Medical Sciences and Memorial Sloan-Kettering Cancer Center. His work has resulted in over 20 publications and multiple patents/patent applications.