Suppressing β-catenin translocation to the nucleus through disruption of the interaction between BCL9 and β-catenin allows for disruption of oncogenic Wnt-signaling, resulting in tumor cell death and a pro-inflammatory tumor microenvironment – without disruption of homeostatic Wnt-function

ST316 suppresses transcription of Wnt target genes regulating proliferation, migration, invasion and the metastatic potential of tumor cells, as well as genes regulating the immunosuppression of the tumor microenvironment.