Research Associate – Discovery

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Employment Status: Full-Time

About Sapience Therapeutics

Sapience Therapeutics, Inc. is a privately held, clinical-stage biotechnology company focused on discovering and developing peptide therapeutics to address oncogenic and immune dysregulation that drive cancer.  With in-house discovery capabilities, Sapience has built a pipeline of therapeutic candidates called SPEARs™ (Stabilized Peptides Engineered Against Regulation) that disrupt intracellular protein-protein interactions, enabling targeting of transcription factors which have traditionally been considered undruggable. Sapience is also directing cargo to cell surface targets with a new class of molecule called SPARCs™ (Stabilized Peptides Against Receptors on Cancer), enabling delivery of payloads such as α-particles to cancer cells.  Sapience is advancing its lead programs, lucicebtide (formerly known as ST101), a first-in-class antagonist of C/EBPβ, and ST316, a first-in-class antagonist of β-catenin, through Phase 2 clinical trials. 

Position Summary:

We are seeking a highly motivated and meticulous researcher to support the discovery and characterization of peptide candidates. The ideal candidate will be someone who enjoys working in a collaborative and fast-paced environment. The candidate will be involved in peptide discovery efforts utilizing Sapience’s ADAPT™ and PADS™ platforms. The candidate will perform genomic and cell-based assays to support peptide candidate discovery and optimization.

Responsibilities:

  • Support duties related to the parallel progress of multiple projects.
  • Keep up-to-date and well-organized records of experiments.
  • Communicate effectively and transparently.
  • Participate in meetings and present their work to the group
  • Be able to work collaboratively with a diverse group of people from all backgrounds.
  • Perform other related duties as necessary to ensure the proper functioning of the laboratory.

Requirements:

  • A minimum of bachelor’s degree in cell biology, biochemistry, molecular biology, or a closely related field.
  • Molecular biology skills such as DNA/RNA isolation, PCR, molecular cloning and vector design and construction, Western blotting, and gel electrophoresis are required.
  • Experience with mammalian cell culture, reporter assays, viability assays and flow cytometry is preferred.
  • Experience with data analysis using Microsoft Office and Prism.

What We Offer

  • A diverse and inclusive culture where ideas are shared and your authentic self is welcome.
  • Exceptional, collaborative, dedicated team.
  • The opportunity to participate in work which may have a transformational impact on patients’ lives.
  • Continuous learning and dynamic challenges to help you grow and be the best version of yourself.
  • Comprehensive health/dental/vision insurance, 401k match, stock options, PTO.
  • Compensation and job title will be commensurate with experience, skills, and education.
  • Training will be provided to the right candidate.

How to Apply

Please submit your CV and cover letter in PDF format to careers@sapiencetherapeutics. Please indicate the position title in the subject line of your email. We will contact you should we wish to arrange a meeting to discuss this position further.

Sapience Therapeutics is an equal opportunity employer. We recognize the power and importance of a diverse employee population and strongly encourage applicants with various experiences and backgrounds.