Scientist/Senior Scientist, Research

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Employment Status: Full-Time

About Sapience Therapeutics

At Sapience, we think boldly about the possibilities for treating cancer. We aim to discover and develop peptide therapeutics to address oncogenic and immune dysregulation that drive cancer. To accomplish this goal, we are developing next generation peptide therapeutic candidates called SPEARS (Stabilized Peptides Engineered Against Regulation) to drug oncogenic transcription factors and regulatory pathways of disease that make cells cancerous or dampen the immune systems response against tumors. Our lead compound, ST101, is currently in the Phase 2 portion of a Phase 1/2 clinica trial and has demonstrated clinical proof-of-concept in cutaneous melanoma and recurrent GBM.

Position Summary:

We are seeking a highly motivated and productive Scientist who wants to be part of an innovative team focused on discovering and developing peptide-based therapeutics to previously ‘undruggable’ targets for major unmet medical needs, particularly high mortality cancers. The individual will work independently to design, execute, interpret, and optimize molecular and cellular biological assays to support discovery and development stage projects.

The ideal candidate will demonstrate strong intellectual curiosity, experimental independence, and a passion to develop new therapeutics. The scientist will be expected to initiate new avenues of research, as well as support ongoing projects.

Key Responsibilities:

  • Develop and conduct target engagement studies using flow cytometry, immunoblotting, co-immunoprecipitation, immunofluorescence, and related methods.
  • Design, conduct, interpret and optimize biochemical and cellular experiments to discover and characterize protein-protein and peptide-protein interactions.
  • Communicate project results at meetings; provide scientific results that support the generation of publications and patents.
  • Keep up-to-date and well-organized records of experiments.
  • Contribute to identifying and managing CROs for offsite analyses.
  • Contribute effectively to patents, reports, and publications of scientific findings.

Key Requirements:

  • A minimum of a Ph.D. in biology, biochemistry, or a related field.
  • Deep understanding of tumor biology.
  • A minimum of 5 years industrial experience is preferred.
  • Demonstrated expertise in molecular biology and protein engineering required.
  • Experience with mammalian cell culture, cell engineering, reporter assays, protein analysis required.
  • Experience in assay development for target engagement and biomarker discovery preferred.
  • A proven history of independent investigations, innovative thinking, time and effort management, strong interpersonal skills, and a demonstrated ability to collaborate.

What We Offer

  • A diverse and inclusive culture where ideas are shared and your authentic self is welcome
  • Exceptional, collaborative, dedicated team
  • The chance to participate in work which may have a transformational impact on millions of people
  • Continuous learning and dynamic challenges to help you grow and be the best version of yourself
  • Comprehensive health/dental/vision insurance, 401k match, stock options, PTO

How to Apply

To apply online, please fill out the form below. If you prefer to send a letter, resume or curriculum vitae to careers@sapiencetherapeutics.com please indicate the position title in the subject line of your email. We will contact you should we wish to arrange a meeting to discuss this position further.

Sapience Therapeutics is an equal opportunity employer. We recognize the power and importance of a diverse employee population and strongly encourage applicants with various experiences and backgrounds.